Dr. Suvarn Kulkarni

    Assistant Professor

    Department of Chemistry

    Indian Institute of Technology Bombay

    Powai, Mumbai 400076

    

    Ph:   022-2576 7166     

    Fax: 022 -2576 7152

    Email: suvarn[at]chem.iitb.ac.in

    Group Webpage

Academic Background

Ph. D. in Chemistry, 2001, University of Pune.


Professional Experience

Academia Sinica Post-doctoral Fellow - Academia Sinica, Taiwan (June 2001- Sept 2005)

Assistant Specialist - University of California Davis (Oct 2005 - July 2008)

Assistant Professor - Indian Association for the Cultivation of Science (Nov 2008 - Jan 2009)

Assistant Professor - Indian Institute of Technology Bombay (Feb 2009 -)

 

Research Interests

 

  • One-pot methods for glycomics.
  • Synthesis of cell-surface carbohydrates - oligosaccharides, glycolipids and glycoconjugates.
  • Study of carbohydrate recognition in cancer and mycobacterial infections.

Representative Publications:

       
  • "Synthesis of Maradolipid" Sarpe, V. A.; Kulkarni, S. S. J. Org. Chem. 2011,76, 6866-6870.

  • "Development of Sodium-Dependent Glucose Co-Transporter 2 Inhibitors as Potential Anti-Diabetic Therapeutics" Ho, L.-T.; Kulkarni, S. S.; Lee, J.-C. Curr. Top. Med. Chem. 2011, 11, 1476-1512.

  • "Rapid Transformation of D-Mannose into Orthogonally Protected D-Glucosamine and D-Galactosamine Thioglycosides" Emmadi, M.; Kulkarni, S. S. J. Org. Chem. 2011, 76, 4703-4709.

  • One-Pot Syntheses of Immunostimulatory Glycolipids Schombs, M.; Park, F. E.; Du, W.; Kulkarni S. S.; Gervay-Hague, J.,  J. Org. Chem. Featured Article, 2010, 2010, 75, 4891-4898

  • "Synthesis of Alginate Oligosaccharides Containing L-guluronic acids" Chi, F.-C.; Kulkarni, S. S.; Medel Manuel L. Z.; Hung, S.-C. Chem. Asia. J. 2009, 4, 386-390

  • "Two-step Synthesis of the Immunogenic Bacterial Glycolipid BbGL1". Kulkarni S. S ; Gervay-Hague, J. Org. Lett. 2008, 10, 4739-4742

  • "Regioselective One Pot Protection of Glucose" Wang, C.-C.; Kulkarni, S. S.; Lee J.-C.; Luo, S.-Y.; Hung S.-C. Nature Protocols 2008, 3, 97-113

  • "Regioselective and One Pot Protection of Carbohydrates" Wang, C.-C.; Lee J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung S.-C. Nature 2007, 446, 896-899

  • "Efficient, One-Pot Syntheses of Biologically Active alpha-linked Glycolipids" Du, W.; Kulkarni, S. S.; Gervay-Hague, J. Chem Commun 2007, 2336-2338

  • "Efficient Synthesis of a C-Analog of the Immunogenic Bacterial Glycolipid BbGL2". Kulkarni S. S ; Gervay-Hague, J. Org. Lett. 2006, 8, 5765-5768

  • "Synthesis of 48 Disaccharide Building Blocks for the Assembly of Heparin and Heparan Sulfate Oligosaccharide Library." Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C. Org. Lett. 2006, 8, 5995-5998

  • "A Concise Synthesis of Tetrahydroxy-LCB, alpha-Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks" Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C. J. Org. Chem. 2006, 71, 1226-1229

  • "2-Allyloxyphenyl Glycoside as a New and Stable Type of Glycosyl Donors" Lee, J.-C.; Pan, G.-R.; Kulkarni, S. S., Luo, S.-Y; Liao, C.-C.; Hung, S.-C. Tetrahedron Lett. 2006, 47, 1621-1624

  • "Neighboring Group Participation of 9-Anthracenemethyl Group in Glycosylation: Preparation of Unusual C-glycosides", Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C. J. Org. Chem. 2005, 70, 2808-2811

  • "Metal Trifluoromethanesulfonates as Versatile Catalysts in Carbohydrate Synthesis" Kulkarni, S. S.; Hung, S.-C. Lett. Org. Chem. 2005, 2, 670-677

  • "Cu(OTf)2-catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals" Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C. Angew. Chem. Int. Ed. 2005, 44, 1665-1668

  • "Synthesis of Heparin Oligosaccharides", Lee, J.-C.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C. J. Am. Chem. Soc. 2004, 126, 476-477

  • "Recent Advances in the Applications of D- and L-1,6-Anhydropyranoses for the Synthesis of Oligosaccharides and Nature Products", Kulkarni, S. S.; Lee, J.-C.; Hung, S.-C. Curr. Org. Chem. 2004, 8, 475-509

  • "Biologically Potent L-Hexoses and 6-Deoxy-L-hexoses: Their Syntheses and Applications", Kulkarni, S. S.; Chi, F.-C.; Hung, S.-C. J. Chin. Chem. Soc. 2004, 51(Special Issue dedicated to Prof. Sunney I. Chan to celebrate his 67th Birthday), 1193-1200

  • "Regioselective Glycosylation of Neamine Core: A Facile Entry to Kanamycin B-Related Analogues", Chou, C.-H; Wu, C.-S.; Chen, C.-H.; Lu, L.-D.; Kulkarni, S. S.; Wong, C.-H.; Hung, S.-C. Org. Lett. 2004, 6, 585-588

  • "From D-Glucose to Biologically Potent L-Hexoses: Synthesis of alpha-L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate", Lee, J.-C.; Chang, S.-W.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C. Chem. Eur. J. 2004, 10, 399-415

  • "Cu(OTf)2-catalyzed Neat Per-O-acetylation of Hexoses with Stoichiometric Amount of Acetic Anhydride and One-Pot Solvent-free Per-O-acetylation-substitution to the Corresponding Thioglycosides", Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C. J. Org. Chem. 2003, 68, 8719-8722

  • "Cu(OTf)2-catalyzed Et3SiH-reductive Etherification of Various Carbonyl Compounds with Trimethylsilyl Ethers", Yang, W.-C.; Lu, X.-A.; Kulkarni, S. S.; Hung, S.-C. Tetrahedron Lett. 2003, 44, 7837-7840

Patents

 

  • One pot synthesis of unprotected alpha/beta-O-glycolipids' Gervay-Hague J.; Du, W.; Kulkarni, S. S.; Schombs, M. PCT Int. Appl.(2008), WO 2008124729 A1 20081016

Book Chapters

 

  • "Synthesis of Hemagglutinin-Binding Trisaccharides" Wang, C.-C.; Kulkarni , S. S.; Zulueta, M. M. L.; Hung, S.-C. In 'The Molecular Immunology of Complex Carbohydrates-3, Advances in Experimental Medicine and Biology 705, Springer Science+Business Media, LLC, 2011, Chapter 37, pp 691-726.

  • Glycosyl chlorides, bromides and iodides, Kulkarni, S.S. and Gervay-Hague, J. Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance, Demchenko, A. V. Eds., Wiley-VCH, 2008, pp59-93

  • Synthesis of glycolipid antigens, Kulkarni, S.S, and Gervay-Hague, J. In Chemical Glycobiology, Eds. Chen, X.; Halcomb, R.; Wang, P. G., ACS Symposium series 2008, 990, pp153-166