Nandita Madhavan

Associate Professor

Room 426, Chemistry Bldg.
+91 22 2576 7164
Educational Background:

Ph. D., Univ. of Illinois at Urbana-Champaign, USA
M. Sc., IIT Bombay
B. Sc., S. I. E. S. College, Mumbai

Professional Experience:

Post-doc,Univ. of Illinois at Urbana-Champaign, USA
Assistant Professor, IIT Madras (2009)
Associate Professor, IIT Madras (2015)
Associate Professor, IIT Bombay (2016)

Research Interest:

Our goal is to engineer biomimetic molecules using organic synthesis as a tool and amino acids as building blocks. We exploit the functional group diversity of amino acids and the hydrogen bonding capability of peptides to develop interesting 3-dimensional supramolecular structures. In particular, we mimic natural pore forming proteins or ion channels found in the cell membranes. The ion selectivity and the reversible opening-closing or “gating” behaviour of these molecules can be potentially used for the development of therapeutics and molecular switches.

Specific research focus areas:
· Peptide Synthesis - Development of improved supports and coupling reagents.
· Self-Assembly - Design of robust three-dimensional peptide derived pores.
· Function – Design of selective and gated synthetic ion channels.

 

Publications:
Saha, Parichita; Agarwala, Prema Kumari; Dadhich, Ruchika; Adhyapak, Pranav; Kapoor, Shobhna; Madhavan, Nandita.
ChemBioChem 2021, 22.

B. P.; Behera, H., Madhavan, N.
Eur. J. Org. Chem. 2020, 44, 6898-6902.

Saha, P; Madhavan, N.
Organic Lett. 2020, 22, 5104-5108.

Erapalapati, V.; Hale, U. H.; Madhavan, N.
Tetrahedron Lett. 2019, 60, 151311; Highlighted in Synfacts.

Bisht, B.; Naganna, N.; Madhavan, N.
Org. Biomol. Chem. 2019, 17, 7238-7246.