CH 524 : Bioorganic Chemistry


Introductory awareness of the role of metal ions in biology and medicine. A quick refresh of the general features of coordination chemistry, bio-molecules, spectral and biochemical techniques.Bioinorganic approach with respect to the following aspects: Transport of alkali and alkaline earth ions and functioning of ATPases. Vanadium in haloperoxidases and nitrogenases. Role of manganese in the oxygen evolution cluster of photosystem – II. Iron proteins & Enzymes: Transport & storage; Porphyrin and non-porphyrin based: Electron Transport; Monooxygenases, Dioxygenases; Phosphatases; Reductases; Superoxide dismutase. Cobalt: Cobalamine based enzymes. Nickel: Urease; Hydrogenases; Carbonmonooxide Dehydrogenases. Copper: Electron Transport; Oxidases; Monooxygenases; Dioxygenases; Various types of copper centers; Super oxide dismutase. Zinc: Hydrolases; Peptidases; Lyases; Ligages; Oxido-reductases; Transferases. Molybdenum: Nitrogenase; all types of Oxido-reductases. Selenoenzymes; Nitrosyls in bioinorganic chemistry.

Text References

1) Bioinorganic Chemistry: The Biological Chemistry of Transition Metals, Michael Watkinson, 2009, John Wiley & Sons
2) Principles of Bioinorganic Chemistry, Stephen J. Lippard, Jeremy Mark Berg, 1994, University Science Publications
3) Inorganic Biochemistry: An Introduction, James A Cowan, 1993, VCH Publishing.
4) Handbook on metalloproteins, Ivano Bertini, Astrid Sigel, Helmut Sigel, 2001, CRC Press
5) Bioinorganic chemistry: transition metals in biology and their coordination chemistry, Alfred Trautwein, 1997, Deutsche Forschungsgemeinschaft.
6) Bioinorganic Chemistry- an inorganic perspective of life, D. P. Kessissoglou, 1995, Kluwer Academic.