CH 584 : Biophysical Chemistry
Syllabus
Structure of water. Biological relevance of chemical potential. Hydrophobic and hydrophilic interactions in biological systems. Protein-Solvent Interactions - preferential binding, hydration and exclusion. Protein structure, stability, folding, unfolding and their studies with spectroscopic and calorimetric methods. Protein-Ligand Binding. Structure-Function relationships. Equilibria across membranes.
Text References
- R. B. Gregory, ed., Protein-Solvent Interactions, Marcel Dekker,Inc., 1995.
- B. T. Nall and K. A. Dill, ed., Conformations and Forces in Protein Folding, American Association for the Advancement of Science, 1991.
- C. Branden and J. Tooze, Introduction to Protein Structure, Garland Publishing, Inc., 1991.
- J. Wyman and S. J. Gill, Binding and Linkage : Functional Chemistry of Biological Macromolecules, University Sciences Books, 1990.
- C. R. Cantor and P. R. Schimmel, Biophysical Chemistry, Part III, W.H.Freeman and Co., 1980.