CH 584 : Biophysical Chemistry


Structure of water. Biological relevance of chemical potential. Hydrophobic and hydrophilic interactions in biological  systems. Protein-Solvent Interactions - preferential binding, hydration and exclusion. Protein structure, stability,  folding, unfolding and their studies with spectroscopic and  calorimetric methods. Protein-Ligand Binding. Structure-Function relationships. Equilibria across membranes.

Text References

  1. R. B. Gregory, ed., Protein-Solvent Interactions, Marcel  Dekker,Inc., 1995.
  2. B. T. Nall and K. A. Dill, ed., Conformations and Forces  in Protein Folding, American Association for the Advancement  of Science,  1991.
  3. C. Branden and J. Tooze, Introduction to Protein Structure, Garland Publishing, Inc., 1991.
  4. J. Wyman and S. J. Gill, Binding and Linkage :  Functional Chemistry of Biological Macromolecules,  University Sciences Books, 1990.
  5. C. R. Cantor and P. R. Schimmel, Biophysical Chemistry, Part  III, W.H.Freeman and Co., 1980.