CH 404 : Physical Organic Chemistry/ (Half semester)
Symmetry-adapted orbitals. Mixing rules and buildup approach to molecules and molecular complexes. Energy surface for bond breaking and making. Kinetic vs thermodynamic control, Curtin-Hammett principle, Hammond Postulate Reactive intermediates: Carbocations, carbanions, carbenes, benzyne. Empirical scales for electronic, steric, and solvent effects. Mechanism according to free-energy correlation and correpondence with theory of orbital interaction. Illustrative examples. Linear free energy relationship, Hammett and Taft equations
- E. V. Anslyn and D. A. Dougherty, Modern Organic Chemistry, University Science, 2005.
- A. Pross, Theory and Physical Principles of Organic Reactivity, John Wiley, 1995.
- A. Rauk, Orbital Interaction Theory of Organic Chemistry, John Wiley, 1994.
- T. H. Lowry and K. H. Richardson, Mechanisms and Theory in Organic Chemistry, Harper and Row, 1976.