CH 584 : Biophysical Chemistry


Structure of water. Biological relevance of chemical potential. Hydrophobic and hydrophilic interactions in biological systems. Protein-Solvent Interactions - preferential binding, hydration and exclusion. Protein structure, stability, folding, unfolding and



their studies with spectroscopic and calorimetric methods. Protein-Ligand Binding. Structure-Function relationships. Equilibria across membranes.


Text References

R. B. Gregory, ed., Protein-Solvent Interactions, Marcel Dekker,Inc., 1995.

B. T. Nall and K. A. Dill, ed., Conformations and Forces in Protein Folding, American Association for the Advancement of Science, 1991.

C. Branden and J. Tooze, Introduction to Protein Structure, Garland Publishing, Inc., 1991.

J. Wyman and S. J. Gill, Binding and Linkage : Functional Chemistry of Biological Macromolecules, University Sciences Books, 1990.

C. R. Cantor and P. R. Schimmel, Biophysical Chemistry, Part III, W.H.Freeman and Co., 1980.