Recently, scientists are trying to create next‐generation materials that exhibit spatiotemporal control over their structural and functional characteristics, to attain life-like behavior. This leads to a paradigm shift from near‐equilibrium systems to non‐equilibrium systems that requires continuous supply of fuel (food or energy) to drive them, since few decades. This fuel‐driven approach is inspired by natural systems, which employ biofuels such as adenosine triphosphate (ATP) and guanosine triphosphate (GTP) for autonomous activities. Such dissipative system that operates out-of-equilibrium is the key to the formation of complex patterns. Naturally occurring spatiotemporal patterns typically have a predictable pattern design and are reproducible over several cycles. However, the patterns obtained from artificially designed out-ofequilibrium chemical oscillating networks [e.g., Belousov-Zhabotinsky (BZ) reaction], are unpredictable and difficult to control spatiotemporally, albeit reproducible over subsequent cycles. In this talk, I will discuss and give illustrative examples how we used audible sound, an underrated stimuli by chemists to generate reproducible spatiotemporal patterns in out-of-equilibrium chemical reactions and self-assembling systems in solutions, which act as a guiding physical stimulus. Next, I will narrate the extension of our strategy to systems of higher chemical complexity (enzymatic networks) and developed an experimental methodology for compartmentalization (concentriosome) and carrying out cascade reactions using sound, hitherto unexplored in chemistry. At the end, how we used our strategy to prepare materials under in situ conditions and their arrangement in solution in a predictable fashion will be illustrated.