Methane and other gaseous (C2-C4) alkanes are one of the most abundant carbon-based feedstocks on this planet. They are typically burned off as fuel or used for steam cracking. These processes are energy-intensive and contribute to the release of greenhouse gases. As a result, it’s highly important to develop protocols that allow efficient chemical transformation of these feedstocks. Although rewarding from a sustainability and efficiency standpoint, the functionalization of gaseous alkanes remains challenging due to their extreme inertness. The C–H bonds in gaseous alkanes have high bond dissociation energy (99–105 kcal mol− 1 ) and ionization potential (∼12.5 eV), along with low acidity (pKa ∼50–51). Also, their gaseous nature and low solubility in common organic solvents add further complications. As a result, only a few reports exist documenting their efficient functionalization. In particular, highly versatile transformations such as crosscouplings, asymmetric catalysis, cascade cyclizations etc., remain unreported with methane and other gaseous alkanes. In this regard, we disclosed an arylative cross-coupling of gaseous alkanes with a range of aryl bromides. 1 The reaction involves photocatalytic generation of alkyl radicals from gaseous alkanes and the subsequent nickelmediated cross-coupling of these radicals with aryl bromides. Next, we expanded this strategy for acylative cross-coupling of gaseous alkanes.2 This protocol provides an efficient gateway for the upscaling of gaseous alkanes to high-volume commodity ketones. Following this, we have developed the first cascade cyclization of methane and gaseous alkanes.3 This transformation provides a gateway for rapidly achieving molecular complexity using these simple alkanes. Very recently, we have unlocked the very first asymmetric transformation of C2-C4 alkanes to carry out 1,2-dicarbofunctionalization of olefins.4 All these protocols showcase excellent functional group tolerance while proceeding under mild energy-efficient conditions. These methods offer promising avenues for the valorization of feedstock gaseous alkanes.