Correlated fluctuations in distributions of small molecules, ions, and macromolecules are central to life processes, especially cell-regulation and signaling. Tracking these fluctuations can provide unprecedented insights into how life works and what causes diseases. To track biomolecules, live, we need molecular reporters or sensorsthat can non-invasively permeate living systems and provide information on their spatiotemporal dynamics. The key is, simultaneous imaging of multiple analytes1 in a particular biological location. Multiplexed spatiotemporal-imaging is, however, challenging as: 1 Molecular reporters for individual analytes have to reach the same biological destination, simultaneously; 2. Output signals of the sensors should be orthogonal or non-overlapping. To address the first challenge, we have developed the concept of morphable ‘stitched’ sensors, where molecular reporters for different bio-analytes can be ‘stitched’ together in a made-to-order, modular fashion to develop sensors for multiplexed imaging in a fluorescence imaging platform.2 While fluorescence imaging affords the apt sensitivity for imaging bioanalytes,3-5 simultaneous imaging of more than two bio-analytes via fluorescence becomes complicated due to broad emission features of fluorescence based molecular sensors. Hence, to overcome the second challenge we have developed Activity-Based Alkyne-tag Raman sensors, ABATaRs, for multi-analyte imaging, by leveraging sharp vibrational features of Raman spectra.1 In this talk, I will discuss these recent research directions in our group, through which we are traversing from single-analyte sensing to multiplexed imaging.