Talk by Prof. Arieh Ben-Naim, Department of Physical Chemistry , The Hebrew University of Jerusalem on Hydrophobic Hydrophilic Effects in Protein Folding and Protein-Protein Association

25 Apr 2018
Seminar Room #350
About Speaker
With more than 200 publications and 25 books, Prof. Ben-Naim has made major contributions over 40 years to the theory of the structure of water, aqueous solutions and hydrophobic-hydrophilic interactions. He is mainly concerned with theoretical and experimental aspects of the general theory of liquids and solutions. In 2017, Ben-Naim posted three articles in which three radical ideas were introduced into a field which is considered as classical. The ideas followed from the new definition of entropy based on Shannon's measure of information. The three ideas are, briefly, as follows. First, there is no relationship between either entropy or the second law of thermodynamics and the so called arrow of time. This false association between the Second Law and time was first suggested by Arthur Eddington. Also the Boltzmann's H-Theorem is not about the time dependence of the entropy, but the time dependence of the Shannon's measure of information. In this respect Boltzmann erred in interpreting his (-)H function as entropy. Second, the application of the concept of entropy to the entire universe is unwarranted. This association has its origin in Clausius' statement that the entropy of the World always increases. Clausius, who is credited for the formulation of the second law, did not and could not understand the molecular interpretation of entropy. Unfortunately, the application of the concept of entropy to the entire universe features in many textbooks and in popular science books. This erroneous application is discussed in great detail in Ben-Naim's recent books: The Briefest History of Time, Entropy, the Truth the whole Truth and nothing but the Truth, and in Information, Entropy, Life and the Universe. Third, the application of entropy and the Second Law to living organisms is totally unwarranted. The most famous statement about entropy and life was made by Erwin Schrödinger, in his book What is Life?. In this book, Schrödinger not only discusses entropy and life and associates entropy with disorder, he also "invents" the concept of "negative entropy," which was later renamed negentropy by Léon Brillouin. This erroneous application is further discussed in Ben-Naim's books. Ben-Naim is a modern antagonist of the term entropy. He advocates abandoning the word entropy altogether, and replacing it with "missing information". He also indicates that the Kelvin temperature scale artificially introduces the units of thermodynamic entropy. Because this temperature scale was introduced before the atomic, microscopic nature of matter was widely accepted, the Boltzmann constant was necessary. S = kBlog(W) could be expressed simply as S = log(W), if the energy units for temperature kBT were used.