High predominance of non-canonical structures like quadruplexes in telomeric and subtelomeric regions in human malaria parasite hint towards their critical roles in telomere maintenance and function . Due to differences in telomere dynamics in host and parasite, we focused our efforts on pharmacological targeting of telomeric quadruplexes to selectively disturb par asite’s telomere homeostasis. We observed that targeting the telomeric quadruplex using specific small molecules disturb telomeric/subtelomeric chromatin organization, cause telomere shortening and induce DNA damage which eventually leads to parasite death. Ongoing experiments include identification and characterization of telomere binding proteins to understand the telomere homeostasis in human malaria parasite