There is ample evidence that RNA played acentral role in information storage andcatalysis during early biology1.However, all known ribozymesat dilution,far below their KM(Michaelis-Menten constant),are pronetoadopt inactive conformations and requireunrealistically high RNA and metal-saltconcentrationto overcome inactive conformations and achieve high levels of activity2, 3, 4. Herein, we show that ppm-amounts of various noncharged water soluble polymers, such as,PEG(polyethylene glycol),PVA(polyvinyl alcohol) and othersact as chemical chaperones that enablestrong ribozyme activity even at nanomolar RNAand suboptimalsaltconcentrations. Specifically, we find that for diluted multi-component RNA ligases(R3C)5and RNA cleaving ribozymes(HH)4, 6,ppmamounts of PEG10Kboost ribozyme-substrateinteractions byalmost twoorders of magnitudeandextend the lifetimeof the reactions resulting inup to 12-foldand 6-fold higher product yields, respectively. Furthermore, thesefindingsimplythat traceamounts of suitable polymers in a primitive environment may have been sufficient to boostearly bio-catalysisby orders of magnitude.