Seminar by Dr. Samya Banerjee, Newton International fellow, Department of Chemistry University of Warwick, England on "Unlocking new anticancer strategies with next-generation metallodrugs"
18 Apr 2019
Seminar Room #350
Talk Title : "Unlocking new anticancer strategies with next-generation metallodrugs"
Abstract
Cancer is the leading causes of morbidity and mortality worldwide (WHO),1with ca 14 M new cases and 8.2 M cancer deaths in 2012, predicted to rise by ca. 70% by 2030. However, the most widely used anticancer drugs, Pt-complexes, are not active against all cancers, and suffer from severe side effects and resistance.1,2Importantly, metal compounds possess thelargely unexplored potential to enhance the immunomodulatory effects of chemotherapeutic agents.3Design concepts for metallodrugs are in their infancy and need to be more widely explored.1-5Studies to understandthe mechanisms of actionof metal-baseddrugs havefocused on Pt itself and its attack on DNA. Strategies for the discovery of next-generation metallo-anticancer drugs with novel mechanisms of action include in-situ reduction, targeting other cellular organelles, modulation of the intracellular redox potential, and targeted delivery.1-6In my talk, I will discuss about the potential of 3d-5d metal (EspeciallyVanadium, Rhodium and Iridium) complexesas the next generation tumor selective, cellular organelle targeting anticancer agentsand describetheir detailed mechanism of action.7-11I willalsodiscussour recent research on targeted photoredox catalysisas a brand new approach of cancer treatment.12The novel mechanisms of action and the new targets unlocked by these next-generation metallodrugs have the potential to overcome platinum resistance and to deliver safer and improved chemotherapeuticsto cancer patients