Seminar by Dr. Veera Reddy Yatham, Division of Organic synthesis and process chemistry, CSIR-IICT Hyderabad on "Key Intermediates in NHC-catalysis, Redox Nuetral Carboxylation, Decarboxylation and Ni-catalyzed "
01 Jul 2019
Seminar Room #350
Talk Title : "Key Intermediates in NHC-catalysis, Redox Nuetral Carboxylation, Decarboxylation and Ni-catalyzed "
Abstract
N-heterocyclic carbenescatalyzed Umpolung of aldehydesinvolves theformation ofseveral intermediates i.e. Breslow-intermediates (diamino enols), diamino dienols and azolium enolates.Part of this lecture will be discussed on key Intermediatesin NHC-umpolung of aldehydes(Part-1), address the problemsand the solutionsin NHC-umpolung of enals.Visible-light photocatalysis is a powerful tool to generate various chemical motifs under mild reaction conditions. Most of the chemical reactions are initiated by either Ir, or Ru complexes via singleelectron transfer (SET) throughMetal to Ligand Charge Transfer (MLCT). Also, recently, visible-light induced Ligand to Metal Charge Transfer (LMCT) emerged as a robust alternative to generate radical species by the homolysis of the metal-ligand bond.In this part I will discuss the first example of redox neutral di-carbo functionalization of styrenes with CO2and with carbon radicals (which are generated through MLCTby Ir-complex). Also, I will discuss one example how to utilize simple CeCl3as a photocatalyst through LMCTto get valuable compounds from simple precursors(Part-2), also application of this methodology for the late stage fictionalizations of drug candidates.Most of the metal catalyzed cross coupling reactions was conducted by employing halo compounds as coupling partners.In this context of coupling partners, the abundanceof alkyl amines in pharmaceuticalsand pre-clinical candidatesmakes them to utilize as a coupling partnerin cross-coupling arena will add a significant value to synthetic community.In this part, I willdiscuss a methodology how to utilize these alkyl amines as carbon electrophilein coupling reactions (Part-3), also application this methodology for late fictionalizationof amine containing drugs.