Prof. Bernhard Breit, Institute of Organic Chemistry, University of Freiburg i. Bg. Germany on "Rhodium-Catalyzed Addition of Pronucleophiles to Alkynes and Allenes: An Atom-Efficient Alternative to the Tsuji-Trost Reaction"
11 Mar 2020
Seminar Room #350
Talk Title : "Rhodium-Catalyzed Addition of Pronucleophiles to Alkynes and Allenes: An Atom-Efficient Alternative to the Tsuji-Trost Reaction"
Abstract
Transformation of simple and readily accessible starting materials to branched allylic derivatives is an important topic in organic synthesis because of the versatility of the allylic moiety for further elaboration and the stereogenic center for asymmetricsynthesis.1In the last decades, significant progress toward this goal has been achieved, in particular with allylic substitution1and allylic C-H oxidation2chemistry. However, these methods require pre-installation of a leaving group or stoichiometric amounts of an oxidant, respectively.
