Ligand Induced Cu (II) Transport restricts Cancer and Mycobacterial Growth: Towards a Plug‐and‐Select Ion Channel Scaffold
Saha, Parichita; Agarwala, Prema Kumari; Dadhich, Ruchika; Adhyapak, Pranav; Kapoor, Shobhna; Madhavan, Nandita.
ChemBioChem 2021, 22.
Lipidomic landscape in cancer: Actionable insights for membrane-based therapy and diagnoses
Prema K. Agarwala,Ritu Aneja,Shobhna Kapoor
MedResRev, 2021, 10.1002/med.21868
Switching between blebbing and lamellipodia depends on the degree of non-muscle myosin II activity
Ghosh, Indranil; Singh, Raman K;, Mishra, Manjari; Kapoor, Shobhna; Jana, Siddhartha S.
J. Cell. Sci. 2021, 134.
The Emerging World of Membrane Vesicles: Functional Relevance, Theranostic Avenues and Tools for Investigating Membrane Function
Kapoor, Shobhna; Srivatsav, Aswin T.
Front. Mol. Biosci.
A Virulence-Associated Glycolipid with Distinct Conformational Attributes: Impact on Lateral Organization of Host Plasma Membrane, Autophagy, and Signaling
Dadhich, Ruchika; Mishra, Manjari; Ning, Shangbo; Jana, Santanu; Sarpe, Vikram A; Mahato, Jaladhar; Duan, Mojie; Kulkarni, Suvarn S.; Kapoor, Shobhna.
ACS Chem. Biol. 2020, 15, 740-750.
Design and expeditious synthesis of quinoline‐pyrene based ratiometric fluorescent probes for targeting lysosomal pH
Gharpure, Santosh J.; Kapoor, Shobhna; Hande, Pankaj; Mishra, Manjari; Datta, Anindya; Ali, Fariyad
ChemBioChem 2020, 21, 1492-1498.
Dynamical Organization of Compositionally Distinct Inner and Outer Membrane Lipids of Mycobacteria
Adhyapak,P; Srivatsav, A.T.; M. Mishra, M; Singh, A; Narayan, R; Kapoor. S.
Biophys. J. 2020, 118, 1279-1291
Modulation of host cell membrane nano-environment by mycobacterial glycolipids: Involvement of PI(4,5)P2 signaling lipid?
Mishra, Manjari; Kapoor, Shobhna
Faraday Discuss., 2020, xx, xxxx.
Mycobacterium lipids modulate host cell membrane mechanics, lipid diffusivity, and cytoskeleton in a virulence-selective manner
Mishra, Manjari; Dadhich, Ruchika; Mogha, Pankaj; Kapoor, Shobhna
ACS Infect. Dis. 2020, 6, 2386-2399.
Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis
Dadhich, Ruchika; Singh, Abhishek; Menon, Anjana P; Mishra, Manjari; C.D. Athul; Kapoor, Shobhna.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2019, 1861, 1213-1227
Dynamic Remodeling of the Host Cell Membrane by Virulent Mycobacterial Sulfoglycolipid-1
Mishra, Manjari; Adhyapak, Pranav; Dadhich, Ruchika; Kapoor, Shobhna.
Scientific Reports 2019, 9, 12844.
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119
Cromm, Philipp M.; Adihou, Hélène; Kapoor, Shobhna; Vazquez‐Chantada, Mercedes; Davey, Paul; Longmire, David; Elisabeth, Hennes; Hofer, Walter; Küchler, Philipp; Chiarparin, Elisabetta; Herbert, Waldmann; Grossmann, Tom N.
ChemBioChem 2019, 20,2987 –2990
Membrane Dynamics in Health and Disease: Impact on Cellular Signalling
Adhyapak, Pranav; Kapoor, Shobhna
J. Mem. Biol. 2019, 252, 213–226
The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens
Garlapati, Chakravarthy; Joshi, Shriya; Sahoo, Bikram; Kapoor, Shobhna; Aneja, Ritu.
Frontiers in Bioscience, 2019, 11, 75-88.
The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype
Schneidewind,Tabea; Kapoor, Shobhna; Garivet, Guillaume; Karageorgis, George; Narayan, Rishikesh; Vendrell-Navarro, Gloria; Antonchick, Andrey P.; Ziegler, Slava; and Waldmann, Herbert .
Cell Chem. Biol. 2019, 26, 512-523.e5.
Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways
Brand, Silke; Roy, Sayantani; Schröder, Peter; Rathmer, Bernd; Roos, Jessica; Kapoor, Shobhna; Pati, Sumersing; Pommerenke, Claudia; Maier, Thorsten; Jannin, Petra; Eberth, Sonja; Steinhilber, Dieter; Schade, Dennis; Schneider, Gisbert; Kumar, Kamal; Ziegler, Slava; Waldmann, Herbert;
Cell Chem. Biol., 2018, 25, 1–12
Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
Srivatsav, Aswin T.; Mishra, Manjari; Kapoor, Shobhna;
BioMed Research International, Volume 2018, Article ID 6437371
Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.
Sheremet, Michael; Kapoor, Shobhna; Schroeder, Peter; Kumar, Kamal; Ziegler, Slava; Waldmann, Herbert.
ChemBioChem, 2017, 18, 1797-1806
Novel approaches to map small molecule-target interactions.
Kapoor, Shobhna; Waldmann, Herbert; Ziegler, Slava.
Bioorg. Med. Chem., 2016, 24, 3232-3245
Regulation of K-Ras4B membrane binding by calmodulin.
Sperlich, Benjamin; Kapoor, Shobhna; Waldmann, Herbert; Winter, Roland; Weise, Katrin.
Biophys. J., 2016, 111, 113-122
Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.
Kapoor, Shobhna; Fansa, Eyad K.; Moebitz, Simone; Ismail, Shehab A.; Winter, Roland; Wittinghofer, Alfred; Weise, Katrin.
Biophys. J., 2015, 109, 1619-1629
Pressure - A Gateway to Fundamental Insights into Protein Solvation, Dynamics, and Function.
Luong, Trung Quan; Kapoor, Shobhna; Winter, Roland.
ChemPhysChem, 2015, 16, 3555-3571
Pressure-A Gateway to Fundamental Insights into Protein Solvation, Dynamics, and Function.
Luong, Trung Quan; Kapoor, Shobhna; Winter, Roland.
ChemPhysChem, 2015, 16, 3539
Prebiotic Cell Membranes that Survive Extreme Environmental Pressure Conditions.
Kapoor, Shobhna; Berghaus, Melanie; Suladze, Saba; Prumbaum, Daniel; Grobelny, Sebastian; Degen, Patrick; Raunser, Stefan; Winter, Roland.
Angew. Chem., Int. Ed., 2014, 53, 8397-8401
Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins.
Weise, Katrin; Huster, Daniel; Kapoor, Shobhna; Triola, Gemma; Waldmann, Herbert; Winter, Roland.
Faraday Discuss., 2013, 161, 549-561
Misplaced helix slows down ultrafast pressure-jump protein folding.
Prigozhin, Maxim B.; Liu, Yanxin; Wirth, Anna Jean; Kapoor, Shobhna; Winter, Roland; Schulten, Klaus; Gruebele, Martin.
Proc. Natl. Acad. Sci. U. S. A., 2013, 110, 8087-8092, S8087/1-S8087/14
Pressure Modulation of Ras-Membrane Interactions and Intervesicle Transfer.
Kapoor, Shobhna; Werkmueller, Alexander; Goody, Roger S.; Waldmann, Herbert; Winter, Roland.
J. Am. Chem. Soc., 2013, 135, 6149-6156
Cross-Amyloid Interaction of Aβ and IAPP at Lipid Membranes.
Seeliger, Janine; Evers, Florian; Jeworrek, Christoph; Kapoor, Shobhna; Weise, Katrin; Andreetto, Erika; Tolan, Metin; Kapurniotu, Aphrodite; Winter, Roland.
Angew. Chem., Int. Ed., 2012, 51, 679-683, S679/1-S679/13
Dissociation of the K-Ras4B/PDEδ Complex upon Contact with Lipid Membranes: Membrane Delivery Instead of Extraction.
Weise, Katrin; Kapoor, Shobhna; Werkmueller, Alexander; Moebitz, Simone; Zimmermann, Gunther; Triola, Gemma; Waldmann, Herbert; Winter, Roland.
J. Am. Chem. Soc., 2012, 134, 11503-11510
Investigation of structural changes of β-casein and lysozyme at the gas-liquid interface during foam fractionation.
Barackov, Ivana; Mause, Anika; Kapoor, Shobhna; Winter, Roland; Schembecker, Gerhard; Burghoff, Bernhard.
J. Biotechnol., 2012, 161, 138-146
Revealing conformational substates of lipidated N-Ras protein by pressure modulation.
Kapoor, Shobhna; Triola, Gemma; Vetter, Ingrid R.; Waldmann, Herbert; Winter, Roland.
Biophys. J., 2012, 102, 1468
The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction.
Kapoor, Shobhna; Weise, Katrin; Erlkamp, Mirko; Triola, Gemma; Waldmann, Herbert; Winter, Roland.
Eur. Biophys. J., 2012, 41, 801-813
Zinc-1,4-benzenedicarboxylate-bipyridine frameworks - linker functionalization impacts network topology during solvothermal synthesis.
Henke, Sebastian; Schneemann, Andreas; Kapoor, Shobhna; Winter, Roland; Fischer, Roland A.
J. Mater. Chem., 2012, 22, 909-918
Membrane-Mediated Induction and Sorting of K-Ras Microdomain Signaling Platforms.
Weise, Katrin; Kapoor, Shobhna; Denter, Christian; Nikolaus, Jorg; Opitz, Norbert; Koch, Sebastian; Triola, Gemma; Herrmann, Andreas; Waldmann, Herbert; Winter, Roland.
J. Am. Chem. Soc., 2011, 133, 880-887
Temperature-pressure phase diagram of a heterogeneous anionic model biomembrane system: Results from a combined calorimetry, spectroscopy and microscopy study.
Kapoor, Shobhna; Werkmueller, Alexander; Denter, Christian; Zhai, Yong; Markgraf, Jonas; Weise, Katrin; Opitz, Norbert; Winter, Roland.
Biochim. Biophys. Acta, Biomembr., 2011, 1808, 1187-1195
Effects of surface acidity and pore size of mesoporous alumina on degree of loading and controlled release of ibuprofen.
Das, Shyamal K.; Kapoor, Shobhna; Yamada, Hirotoshi; Bhattacharyya, Aninda J.
Microporous Mesoporous Mater., 2009, 118, 267-272
Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release.
Kapoor, Shobhna; Hegde, Rajesh; Bhattacharyya, Aninda J.
J. Controlled Release, 2009, 140, 34-39
Structure and Function of Hemoglobin Confined Inside Silica Nanotubes.
Kapoor, Shobhna; Mandal, Soumit S.; Bhattacharyya, Aninda J.
J. Phys. Chem. B, 2009, 113, 14189-14195
Ultrasound-Triggered Controlled Drug Delivery and Biosensing Using Silica Nanotubes.
Kapoor, Shobhna; Bhattacharyya, Aninda J.
J. Phys. Chem. C, 2009, 113, 7155-7163
Three-Dimensional Structures of Apo- and Holo-Alanine Dehydrogenase from Mycobacterium tuberculosis Reveal Conformational Changes upon Coenzyme Binding.
Aagren, Daniel; Stehr, Matthias; Berthold, Catrine L.; Kapoor, Shobhna; Oehlmann, Wulf; Singh, Mahavir; Schneider, Gunter.
J. Mol. Biol., 2008, 377, 1161-1173