Ishita Sengupta

Assistant Professor

Room no. 213, 1st Floor, CRNTS, SAIF Bldg.
+91 22 2576 7167
Educational Background:

PhD (The Ohio State University)

Professional Experience:
  • Assistant Professor, IIT Bombay, 2020 - present
  • Assistant Professor, IIT Kanpur, 2018 - 2019.
  • Postdoctoral Fellow, National Centre for Biological Sciences, 2013-2018
Research Interest:

We are broadly interested in studying protein structure and dynamics using biomolecular NMR spectroscopy. In parallel, we will also investigate the physical and conformational changes accompanying complex biomolecular reactions (e.g. protein aggregation) using a variety of biophysical tools. The laboratory will work at the intersection of physical chemistry and structural biology of proteins, using a combination of NMR and other spectroscopic tools, with the help of modern molecular biology and protein biochemistry techniques.

In particular, we will be investigating how long-range interactions (tertiary structure) can tune the local secondary structure of proteins, with the ultimate goal of designing proteins which can reversibly adopt more than one unique fold. This idea has parallels with protein aggregation reactions, which are also often accompanied by drastic conformational changes. More specifically, transient conformational fluctuations in proteins have been hypothesized to initiate protein aggregation and misfolding reactions. We aim to detect these high energy states, modulate their stabilities and lifetimes by protein engineering and binding, and ultimately solve their structures in both the native and the aggregated states.

Motivated individuals with a background in biomolecular NMR spectroscopy and/or protein biophysics are encouraged to apply. Please contact me at with a CV and a short description of your research interests.

Sengupta; Ishita.
J. Chem. Educ. 2021, 98, 1673–1680.

Ishita Sengupta, Suhas H. Bhate, Ranabir Das, and Jayant B. Udgaonkar,
Journal of Molecular Biology, 429 (12), 1852-1872 (2017)

Ishita Sengupta, Philippe S. Nadaud, and Christopher P. Jaroniec,
Accounts of Chemical Research, 46 (9), 2117–2126 (2013)

Ishita Sengupta, Philippe S. Nadaud, Jonathan J. Helmus, Charles D. Schwieters and Christopher P. Jaroniec
Nature Chemistry, 4, 410–417 (2012)