Ph. D., Univ. of Illinois at Urbana-Champaign, USA
M. Sc., IIT Bombay
B. Sc., S. I. E. S. College, Mumbai
Post-Doc, Georgia Institute of Technology
Assistant Professor, IIT Madras (2009)
Associate Professor, IIT Madras (2015)
Associate Professor, IIT Bombay (2016)
Professor, IIT Bombay (2021)
Our goal is to engineer biomimetic molecules using organic synthesis as a tool and amino acids as building blocks. We exploit the functional group diversity of amino acids and the hydrogen bonding capability of peptides to develop interesting 3-dimensional supramolecular structures. In particular, we mimic natural pore forming proteins or ion channels found in the cell membranes. The ion selectivity and the reversible opening-closing or “gating” behaviour of these molecules can be potentially used for the development of therapeutics and molecular switches.
Specific research focus areas:
· Peptide Synthesis - Development of improved supports and coupling reagents.
· Self-Assembly - Design of robust three-dimensional peptide derived pores.
· Function – Design of selective and gated synthetic ion channels.