The research focus of our group is on structural biochemistry. We employ a combination of X-ray crystallographic and biochemical techniques to develop insights into various cellular pathways. In particular, we employ structural information to understand mechanism of catalysis of enzymes involved in select biosynthetic pathways. Our major research areas include study of the mechanism of catalytic coupling and channeling of unstable intermediates in purine metabolism. We also employ a combination of sequence and structural information to decipher structure-activity and evolutionary relationships of enzymes involved in nucleobase deamination.  In addition, our laboratory studies proteins involved in antibiotic production and resistance pathways in various streptomyces species.  Together these studies facilitate in identification and design of novel drug targets and aid in rationally engineering an enzyme with therapeutic applications.