Parameter Specification Sensitivity, MS mode, 500:1 RMS electrospray on-column, 400 μL/min flow rate Sensitivity, MS/MS mode, 1,500:1 RMS electrospray on-column, 400 μL/min flow rate Mass resolving power Greater than 45 ,000 FWHM at m/z 2,722 Mass accuracy – MS mode, electrospray Less than 0.8 ppm RMS as on-column, 400 μL/min measured from 10 repeat injection Mass range m/z 100–10,000 extended mass m/z 50–1,700 or 50–3,200 for both high resolution range and extended dynamic range modes. Quadrupole up to m/z 4,000 Positive to negative swithing 1.5 seconds Spectral acquisition rate, MS mode 50 spectra/second Mass accuracy temperature stability, MS mode 30 MS/MS spectra/second