CH 813

Advanced Bioinorganic Chemistry
Syllabus: 

Principles of Bioinorganic chemistry, selective metalloenzymes, their structure and functions, biomimetic approaches. Electron transfer, long distance electron transfer, Heme Fe-O2 activation, Cyt-c-oxidase, non-heme iron-O2 activation, Cu-oxidases and models, Structure-function relationship of proteins, tuning electron transfer rates with outer coordination sphere interactions, elucidation of mechanism via optical, EPR, XAS, CD, and vibrational spectroscopy.

Photochemistry of natural photosystem (I & II). The chemical evolution of photosystems (PS) and their underlying symmetry. The detailed mechanism of photochemistry in PS-I and PS-II, photo-antenna and energy transduction. Applications of transient optical spectroscopy, EPR, ENDOR, resonance Raman, SERS spectroscopy and electrochemistry to probe their activity.

Text References: 

1. E.I. Solomon and A. B. P. Lever, Inorganic Electronic Structure and Spectroscopy, Volume I, Wiley, 2006.

2. E. I. Stiefel, J. S. Valentine, I. Bertini, H. B. Gray, Biological Inorganic Chemistry. Structure and Reactivity, University Science Books, 2007.

3. S. J. Lippard and J. M. Berg, Principles Of Bioinorganic Chemistry, University Science Books, Mill Valley, California, 1994. 

4. R. E. Blankenship, Molecular Mechanisms of Photosynthesis, Wiley, 2002.