Seminar by Prof. Shun Hirota, Nara Institute of Science and Technology (NAIST), Japan on "3D Domain Swapping of Proteins: Basics and Recent Developments"

04 Jan 2024
Seminar Room # 350, second floor annex

Speaker: Prof. Shun Hirota
Nara Institute of Science and Technology (NAIST),
Japan

Title: “3D Domain Swapping of Proteins: Basics and Recent
Developments”.

Day and Date: Thursday, January 04, 2024

Time: 16.00 Hrs.

Venue: Room no. 350, Chemistry Department
Second floor, Annex

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Hosted by Prof. G. Naresh Patwari

Talk Title : "3D Domain Swapping of Proteins: Basics and Recent Developments"
Abstract
Three-dimensional (3D) domain swapping is a protein oligomerization phenomenon that exchanges the same domain or secondary structural element between molecules. Our research group has shown that various proteins can undergo domain swapping. We found by X-ray crystallographic and spectroscopic analyses that cyt c forms polymers by successive domain swapping, where the C-terminal helix is displaced from its original position in the monomer and cyt c loses its electron transfer function. We have also utilized domain swapping to construct various heme protein assemblies, including nanoring, nanocage, tetrahedron, heterodimer with different active sites, and amyloid fibril. In this lecture, basics and our recent developments of domain swapping will beintroduced together with future prospects.