Identifying Selectivity Filters in Protein Biosensor for Ligand Screening
Sahi,l M., Singh, J., Sahu, S., Pal S.K., ,Yadav A., Anand R*, and Mondal J*.,
JACS Au 2023, 3, 10, 2800–2812
Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases
Singh, J., Raina, R., Vinothkumar, KR., Anand, R*.,
ACS Chemical Biology 2022 17(4): 829–839
Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase
Sharma, N., Singh, S., Tanwar, A.S, Mondal, J., Anand, R*.,
ACS Catalysis 2022, 12, 3 1930–1944.
Deciphering protein microenvironment by using a cysteine specific switch-ON fluorescent probe
Mariyam, Jessy; Ashoka, Anila Hoskere; Gaded, Vandana; Ali, Firoj; Malvi, Harshada; Das, Amitabha; Anand, Ruchi
Org. Biomol. Chem. 2021, xx, xxxx.
Insights into the Dual Shuttle Catalytic Mechanism of Guanine Deaminase
Sen, Asmita; Gaded, Vandana; Jayapal, Prabha; Rajaraman, Gopalan; Anand, Ruchi
J. Phys. Chem. B 2021, 125, 8814–8826.
Structure guided mutagenesis reveals the substrate determinants of guanine deaminase
Singh, Jayanti; Gaded, Vandana; Bitra, Aruna; Anand, Ruchi
J. Strut. Biol. 2021, 213, 107747.
Tunable Multiplexed Whole-Cell Biosensors as Environmental Diagnostics for ppb-Level Detection of Aromatic Pollutants
Roy, Rohita; Ray, Shamayeeta; Chowdhury, Arindam; Anand, Ruchi
ACS Sens. 2021, 6, 1933–1939.
A combinatorial approach involving E. coli cytosine deaminase and 5-fluorocytosine-nanoparticles as an enzyme-prodrug therapeutic method for highly substrate selective in situ generation of 5-fluorouracil
Horo, Himali; Porathoor, Sini; Anand, Ruchi; Kundu, Lal Mohan
J. Drug. Deliv. Sci.Tech., 2020, 58, 101799
Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation
Sharma, Nandini; Ahalawat, Navjeet; Sandhu, Padmani; Strauss, Erick; Mondal, Jagannath; Anand, Ruchi.
Sci. Adv. 2020; 6: eaay7919
Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase
Bhaskara, Sukritee; Steer, David L; Anand, Ruchi; Panjikar, Santosh.
J. Struc. Biol. X, 2020, 4, 100018.
Deciphering Determinants in Ribosomal Methyltransferases That Confer Antimicrobial Resistance
Bhujbalrao, Ruchika; Anand, Ruchi
J. Am. Chem. Soc., 2019, 141 (4), 1425–1429
Use of 6‐Methylisoxanthopterin, a Fluorescent Guanine Analog, to Probe Fob1‐Mediated Dynamics at the Stalling Fork Barrier DNA Sequences
Mariam; Jessy; Krishnamoorthy, G; Anand, Ruchi
Chem. Asian J. 2019, 14, 4760-4766.
Design of Protein-Based Biosensors for Selective Detection of Benzene Groups of Pollutants
Ray, S., Panjikar, S., Anand, Ruchi
Acs. Sens., 2018, 3, 1632-1638
Design of Ultrasensitive Protein Biosensor Strips for Selective Detection of Aromatic Contaminants in Environmental Wastewater
Ray S., Senapati, T, Sahu, S; Bandyopadhyaya, R, Anand, Ruchi
Anal. Chem., 2018, 90 (15), 8960–8968
Erratum to: Fluorescence Quenching Studies of γ-Butyrolactone-Binding Protein (CprB) from Streptomyces coelicolor A3 (2)
Mariam, Jessy; Anand Ruchi
Quorum Sensing, 2018, E1-E1
Fluorescence quenching studies of γ-butyrolactone-binding protein (CprB) from streptomyces coelicolor A3(2)
Mariam, Jessy; Anand, Ruchi
Methods in Molecular Biology 2018, 1673, 131-143
Nucleobase Deaminases as potential enzymes for new therapies
Gadeda Vandana, Anand Ruchi
RSC Adv., 2018, 8, 23567-23577
Functional insights into the mode of DNA and ligand binding of the TetR family regulator TylP from Streptomyces fradiae.
Ray, Shamayeeta; Maitra, Anwesha; Biswas, Anwesha; Panjikar, Santosh; Mondal, Jagannath; Anand, Ruchi.
J. Biol. Chem., 2017, 292, 15301-15311
Rassf Proteins as Modulators of Mst1 Kinase Activity.
Bitra, Aruna; Sistla, Srinivas; Mariam, Jessy; Malvi, Harshada; Anand, Ruchi.
Sci. Rep., 2017, 7, 45020
Selective Deamination of Mutagens by a Mycobacterial Enzyme.
Gaded, Vandana; Anand, Ruchi.
J. Am. Chem. Soc., 2017, 139, 10762-10768
Site-Specific Fluorescence Dynamics To Probe Polar Arrest by Fob1 in Replication Fork Barrier Sequences.
Biswas, Anwesha; Mariam, Jessy; Kombrabail, Mamta; Narayan, Satya; Krishnamoorthy, G.; Anand, Ruchi.
ACS Omega, 2017, 2, 7389-7399
Structural and dynamics studies of the TetR family protein, CprB from Streptomyces coelicolor in complex with its biological operator sequence.
Bhukya, Hussain; Jana, Asis K.; Sengupta, Neelanjana; Anand, Ruchi.
J. Struct. Biol., 2017, 198, 134-146
Structure Guided Design of Protein Biosensors for Phenolic Pollutants.
Ray, Shamayeeta; Panjikar, Santosh; Anand, Ruchi.
ACS Sens., 2017, 2, 411-418
TetR Regulators: A Structural and Functional Perspective
Bhukya Hussain; Anand, Ruchi
Journal of the Indian Institute of Science, 2017, 97(2), 245-259
Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator.
Ray, Shamayeeta; Gunzburg, Menachem J.; Wilce, Matthew; Panjikar, Santosh; Anand, Ruchi.
ACS Chem. Biol., 2016, 11, 2357-2365
Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining 3D-RISM theory with experiment.
Tanwar, Ajay S.; Sindhikara, Daniel J.; Hirata, Fumio; Anand, Ruchi.
ACS Chem. Biol., 2015, 10, 698-704
Mode of DNA binding with γ-butyrolactone receptor protein CprB from Streptomyces coelicolor revealed by site-specific fluorescence dynamics.
Biswas, Anwesha; Narayan, Satya; Kallianpur, Mamata V.; Krishnamoorthy, G.; Anand, Ruchi.
Biochim. Biophys. Acta, Gen. Subj., 2015, 1850, 2283-2292
Fluorescence Quenching Studies of γ-Butyrolactone Binding Protein (CprB) from Streptomyces coelicolor A3(2).
Biswas, Anwesha; Swarnkar, Ravi K.; Hussain, Bhukya; Sahoo, Suraj K.; Pradeepkumar, P. I.; Patwari, G. Naresh; Anand, Ruchi.
J. Phys. Chem. B, 2014, 118, 10035-10042
Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2).
Bhukya, Hussain; Bhujbalrao, Ruchika; Bitra, Aruna; Anand, Ruchi.
Nucleic Acids Res., 2014, 42, 10122-10133
Diversity oriented approach to triazole based peptidomimetics as mammalian sterile 20 kinase inhibitors.
Kotha, S.; Goyal, D.; Bitra, A.; Thota, N.; Kruger, G.; Anand, R.
RSC Adv., 2013, 3, 24447-24454
Identification of Function and Mechanistic Insights of Guanine Deaminase from Nitrosomonas europaea: Role of the C-Terminal Loop in Catalysis.
Bitra, Aruna; Hussain, Bhukya; Tanwar, Ajay Singh; Anand, Ruchi.
Biochemistry, 2013, 52, 3512-3522
Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis.
Tanwar, Ajay Singh; Goyal, Venuka Durani; Choudhary, Deepanshu; Panjikar, Santosh; Anand, Ruchi.
PLoS One, 2013, 8, e77781
Structural Basis of the Substrate Specificity of Cytidine Deaminase Superfamily Guanine Deaminase.
Bitra, Aruna; Biswas, Anwesha; Anand, Ruchi.
Biochemistry, 2013, 52, 8106-8114
Formylglycinamide ribonucleotide amidotransferase from Salmonella typhimurium: role of ATP complexation and the glutaminase domain in catalytic coupling.
Tanwar, Ajay Singh; Morar, Marya; Panjikar, Santosh; Anand, Ruchi.
Acta Crystallogr., Sect. D: Biol. Crystallogr., 2012, 68, 627-636
Toward the Development of a Potent and Selective Organoruthenium Mammalian Sterile 20 Kinase Inhibitor.
Anand, Ruchi; Maksimoska, Jasna; Pagano, Nicholas; Wong, Eric Y.; Gimotty, Phyllis A.; Diamond, Scott L.; Meggers, Eric; Marmorstein, Ronen.
J. Med. Chem., 2009, 52, 1602-1611
Biochemical Analysis of MST1 Kinase: Elucidation of a C-Terminal Regulatory Region.
Anand, Ruchi; Kim, Ah-Young; Brent, Michael; Marmorstein, Ronen.
Biochemistry, 2008, 47, 6719-6726
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Brent, Michael M.; Anand, Ruchi; Marmorstein, Ronen.
Structure (Cambridge, MA, U. S.), 2008, 16, 1407-1416
Structure and mechanism of lysine-specific demethylase enzymes.
Anand, Ruchi; Marmorstein, Ronen.
J. Biol. Chem., 2007, 282, 35425-35429
Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily.
Morar, Mariya; Anand, Ruchi; Hoskins, Aaron A.; Stubbe, JoAnne; Ealick, Steven E.
Biochemistry, 2006, 45, 14880-14895
A Model for the Bacillus subtilis Formylglycinamide Ribonucleotide Amidotransferase Multiprotein Complex.
Anand, Ruchi; Hoskins, Aaron A.; Bennett, Eric M.; Sintchak, Michael D.; Stubbe, JoAnne; Ealick, Steven E.
Biochemistry, 2004, 43, 10343-10352
Domain Organization of Salmonella typhimurium Formylglycinamide Ribonucleotide Amidotransferase Revealed by X-ray Crystallography.
Anand, Ruchi; Hoskins, Aaron A.; Stubbe, JoAnne; Ealick, Steven E.
Biochemistry, 2004, 43, 10328-10342
Structures of Purine 2'-Deoxyribosyltransferase, Substrate Complexes, and the Ribosylated Enzyme Intermediate at 2.0 Å Resolution.
Anand, Ruchi; Kaminski, Pierre Alexandre; Ealick, Steven E.
Biochemistry, 2004, 43, 2384-2393
The Formylglycinamide Ribonucleotide Amidotransferase Complex from Bacillus subtilis: Metabolite-Mediated Complex Formation.
Hoskins, Aaron A.; Anand, Ruchi; Ealick, Steven E.; Stubbe, JoAnne.
Biochemistry, 2004, 43, 10314-10327
Designer Gene Therapy Using an Escherichia coli Purine Nucleoside Phosphorylase/Prodrug System.
Bennett, Eric M.; Anand, Ruchi; Allan, Paula W.; Hassan, Abdalla E. A.; Hong, Jeong S.; Levasseur, Dana N.; McPherson, David T.; Parker, William B.; Secrist, John A.; Sorscher, Eric J.; Townes, Tim M.; Waud, William R.; Ealick, Steven E.
Chem. Biol., 2003, 10, 1173-1181
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 Å resolution.
Anand, Ruchi; Dorrestein, Pieter C.; Kinsland, Cynthia; Begley, Tadhg P.; Ealick, Steven E.
Biochemistry, 2002, 41, 7659-7669